EyeKor
An Imaging Company for Ophthalmic Clinical Trials
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Age-Related Macular Degeneration

Age-Related Macular Degeneration

Simultaneous Autofluorescence and SD-OCT

AMD or Age Related Macular Degeneration is a common eye condition and a leading cause of vision loss among people age 50 and older. It is one of the leading areas of clinical studies in ophthalmology. This disease is primarily broken into two separated subtypes, Dry AMD and Neovascular or Wet AMD. Currently there is no cure for either subtype however great advancements have been made in the control of Wet AMD and continuing advances and ongoing clinical studies are under way into Dry AMD.

The typical imaging modalities used to document, categorize and monitor treatment of AMD include:

  • Fundus Photography to document the lesion type
  • Fluorescein Angiography to identify any neovascularization  present
  • Optical Coherence tomography to identify and quantify the presence and location of retinal edema
  • Autofluorescence imaging to clearly identify, measure and quantify the areas and junctional zones of dry AMD or geographic lesions

Modalities and endpoints of choice:

  • Autofluorescence Imaging, When GA area measurement is considered the primary endpoint
  • OCT sublayer analysis may provide exploratory endpoints (RPE and photoreceptor layer  analysis)
  • Color fundus photography, for documentation purpose
  • Fluorescein Angiography, to ensure no leakage at screening
  • Microperimetry has been a device of interest in dry AMD studies
  • OCT-A as a new imaging modality

Dry AMD

  • Dry AMD is emerging as a disease of focus in clinical trials
  • GA area measurement is considered the primary endpoint

 

Dry degeneration or Geographic Atrophy on Autofluorescence imaging and Optical Coherence Tomography


Modalities and endpoints of choice:

  • OCT, central subfield retinal thickness for measuring fluid reduction
  • OCT sublayer analysis may provide exploratory endpoints (SHRM analysis)
  • Color fundus photography, for documentation purpose
  • Fluorescein Angiography, for evaluating leakage and for correlating with OCT structural changes
  • OCT-A as a new imaging modality
  • Specular microscopy, provide safety endpoint for surgical intervention

Neovascular AMD

  • Neovascular AMD continues to be a disease of focus for large Phase 3 registration trials
  • Management of fluid and lesion reduction correlating with visual acuity improvement provides the primary endpoints

Wet AMD on Fluorescein Angiography and Optical Coherence Tomography